HIV in Children
July 2015 NEWSLETTER


HIV IN CHILDREN
July 2015 Newsletter
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GRAND ROUNDS
A 12 years 10 month old HIV infected boy has been on ART since the age of 2½ years. He has received multiple antiretrovirals in form of zidovudine (AZT), lamivudine (3TC), stavudine (d4T), didanosine (ddI), nevirapine (NVP) and nelfinavir (NFV). His current viral load is 15,000 copies/ml and CD4 count is 595 (17.3%) cells/cumm. His HIV resistance testing showed resistance to NFV and Atazanavir-ritonavir among the protease inhibitors (PI), resistance to NVP and Efavirenz (EFV) among the NNRTI and M41L, E44D, D67N, V75M, V1181, L210W and T215Y mutation suggestive of thymidine analogue mutations (TAMS) leading to high level resistance to abacavir (ABC), AZT, d4T, ddI and intermediate level resistance to tenofovir (TDF) and low level resistance to 3TC and emtricitabine (FTC) among NRTIs. The child was then started on TDF+FTC+Lopinavir-ritonavir (LPVr) and is on regular follow up.

What are thymidine analogue mutations?

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Question Of the Day
A 10 years old female child is newly diagnosed as HIV positive. She has taken ATT 5 yrs back. Her CD4 count is 426. She s asymptomatic for TB. Should we start ART in this child?
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Pediatric Oncall Book Store
NEW ARRIVAL
Infection in Children - Part 2

By Dr. Ira Shah
Case Rounds in Pediatric Liver Disorders
By Dr. Ira Shah
Tuberculosis
By Dr. Ira Shah
Management of Pediatric HIV
By Dr. Ira Shah
Infection in Children
By Dr. Ira Shah