Ganciclovir |
Induction phase
5 mg/kg every 12 hours IV for 14-21 days [in disseminated disease & CMV retinitis]
6 mg/kg every 12 hours IV for 6 weeks [in symptomatic congenital infection]
Prophylaxis
30 mg/kg tid PO
OR 5 mg/kg/day IV x 5 days/week |
Neutropenia, Myelosuppression, Renal toxicity, CNS effects, GI dysfunction, thrombophlebitis and elevated liver enzymes |
Combination therapy with Ganciclovir & Foscarnet can be used in children with sight threatening disease. |
Foscarnet |
60 mg/kg tid IV for 14-21 days, then 90-120 mg/kg once a day for chronic suppression. |
Renal dysfunction, Electrolyte imbalance (especially in calcium, phosphorus, magnesium and potassium levels), seizures, cardiac arrhythmias, elevated liver enzymes and CNS symptoms |
Used in induction phase as alternative in case of ganciclovir resistant CMV |
